Bouke Hazenberg
University Groningen, UMCG, The Netherlands
E-mail: b.p.c.hazenberg@int.umcg.nl
Phone: + 31 50 361 3432
Overall research program
Groningen Unit for Amyloidosis Research & Development (GUARD). GUARD is a closely collaborating group of various medical disciplines of the University Medical Center Groningen in continuously changing composition, depending on the needs of the patient. All specialists are dedicated to diagnostic and therapeutic aspects of the field of systemic amyloidosis. The disciplines most actively involved are the Departments of Rheumatology and Clinical Immunology (Martin van Rijswijk, Bouke Hazenberg, Johan Bijzet, Pieter Limburg, Ingrid van Gameren, Reinhard Bos), Hematology (Edo Vellenga), Nephrology (Ron Gansevoort), Gastroenterology and the Liver transplant team (Els Haagsma), Nuclear Medicine (Pieter Jager), Neurology (Jan Kuks), Otolaryngology (Freek Dikkers), Cardiology, Pathology, Genetics and the Laboratory Center. The Department of Rheumatology and Clinical Immunology plays a coordinating role among these different specialties.
Our aims are:
1. to improve the diagnostic possibilities and treatment of patients with amyloidosis
2. and to provide information to these patients and their doctors.
Five key publications
1. Hazenberg BP, Limburg PC, Bijzet J, van Rijswijk MH. A quantitative method for
detecting deposits of amyloid A protein in aspirated fat tissue of patients with
arthritis. Ann Rheum Dis 1999; 58:96-102
2. Reyners AK, Hazenberg BP, Reitsma WD, Smit AJ. Heart rate variability as a
predictor of mortality in patients with AA and AL amyloidosis. Eur Heart J 2002;
3:157-61
3. van Gameren II, Hazenberg BP, Jager PL, Smit JW, Vellenga E. AL amyloidosis
treated with induction chemotherapy with VAD followed by high dose melphalan and
autologous stem cell transplantation. Amyloid 2002; 9:165-74
4. Hazenberg BP, van Rijswijk MH, Piers DA, Lub-de Hooge MN, Vellenga E, Haagsma
EB, Hawkins PN, Jager PL. Diagnostic performance of 123I -labeled serum amyloid
P component scintigraphy in patients with amyloidosis. Am J Med 2006;
119:355.e15-24
5. van Gameren II, Hazenberg BP, Bijzet J, van Rijswijk MH. Diagnostic accuracy of
subcutaneous abdominal fat tissue aspiration for detecting systemic amyloidosis
and its utility in clinical practice. Arthritis Rheum 2006; 54:2015-21