• Project summary
• WP 1 Understanding misfolding, amyloid and toxicity
• WP 2 Dissection of the amyloid deposits
• WP3 Genetic analyses
• WP4 Animal models
• WP5 Development and resolution
• WP6 Development of diagnostic procedures and clinical parameters
• WP7 Development of treatments

WP4 Animal models

Animal models are pivotal to understand pathogenesis of amyloidoses and to test therapeutic approaches. Our objectives are to study both common pathways and unique pathogenic features of the specific protein precursor. We have available or are in the process of improving existing mouse or fly models for ATTR, ApoAI, AL and ALys amyloidoses. Common topics of research and methodologies among these models that need in depth study are:
(i)  Composition and distribution of amyloid/aggregate deposits
(ii)  Expression of disease-associated markers
(iii) Modulation of phenotypes by crossing back with specific strains of mouse or fly
(iv) Drug testing